| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new cephalosporin derivative being the specific one, having a wide range antimicrobial spectrum and a strong antibacterial activities and useful as an antimicrobial agent effective in methicillin resistant Staphylococcus aureus(MRSA). SOLUTION: This new cephalosporin derivative is the new one of formula I [R<1> is a (substituted) alkylthio, an aryl, an arylthio, an aryloxy or a heterocyclic ring; A is a (protected) amino, a (protected) OH or a (substituted) methylene; R<2> is a halogen, cyano, amidino, azido, nitro, a (substituted) alkyl, a (substituted) aryl, a (substituted) alkoxy, a (substituted) pyrimidyl, a (substituted) purinyl, a (substituted) quinazolinyl, etc.; R<3> is a (protected) carboxyl, carboxylato; (n) is 0 or 1] and useful as an antimicrobial agent, etc., against the MRSA. This compound is obtained by reacting a cephalosporin derivative of formula II (X is an eliminable group) with mercaptans of the formula R<2> -SH in the presence of a base. |
