| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new peptide producible by the hydrolysis of natural substance such as albumen, having a specific amino acid sequence, exhibiting excellent artery relaxing action and hypotensive action and useful as a hypotensor, an agent for the treatment of stenocardia and myocardial infarction, an agent for improving heart failure, etc. SOLUTION: This new peptide is expressed by the formula H-Arg-Ala-Asp- His-Pro-Phe-OH, exhibits excellent artery relaxing action and hypotensive action and is useful as a hypotensor for the prevention, treatment and diagnosis of hypertension and various states of hypertension, an agent for the treatment of stenocardia and myocardial infarction, an agent for improving the condition of congestive heart failure, etc. The new protein can be produced by diluting albumen of hen's egg with distilled water, adjusting to pH7.4, adding chymotrypsin, hydrolyzing at 37 deg.C for 3hr, concentrating by centrifugal separation after cooling and purifying by high-performance liquid chromatography. |
