发明名称 |
Protein and gene for antioxidant response |
摘要 |
A set of seven nuclear proteins were identified which bind to the antioxidant responsive element (ARE), a DNA sequence present in the promoters of inducible chemoprotective enzymes. One of these ARE binding proteins, here designated ARE-BP-1, has been found to exhibit binding characteristics that parallel the DNA sequences that are necessary for transcriptional induction of the chemoprotective enzymes. ARE-BP-1 is an approximately 160 kDa protein that appears to be a major control switch on the genes which act to protect cells from chemical agents. For binding by ARE-BP-1, a nucleotide sequence must include sequences outside of what was previously through to be the minimally sufficient DNA sequence for inducibility. |
申请公布号 |
AU3658597(A) |
申请公布日期 |
1998.02.10 |
申请号 |
AU19970036585 |
申请日期 |
1997.07.11 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION. |
发明人 |
WILLIAM E. FAHL;WYETH W. WASSERMAN |
分类号 |
A61K38/00;C07K14/47;G01N33/574;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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