CORYDALINE DERIVATIVE-CONTAINING SYNTHESIS INHIBITOR OF PROTEIN BELONGING TO HSP27 FAMILY

摘要

PROBLEM TO BE SOLVED: To obtain the subject synthetic inhibitor capable of suppressing synthesis of heat shock protein and treating disease such as a cancer and a multiple sclerosis, comprising a specific corydaline derivative as an active ingredient. SOLUTION: This synthetic inhibitor comprises a corydaline derivative of formula I (R<1> to R<5> are each independently a 1-3C alkyl) as an active ingredient. A corydaline of formula II is preferable as the corydaline derivative. The corydaline derivative can be extracted from Corydalis Tuber by using water (e. g. cold water warm water or hot water) or an organic solvent. The inhibitor specifically suppresses synthesis of a protein belonging to a heat shock protein having 16 kilodalton to 40 kilodalton molecular weight and is effectively used for preventing and treating a cancer and a multiple sclerosis, etc., whose malignant alteration is related to the protein.