发明名称 |
Kit for detecting the ApoE4 allele, and for diagnosing the existence or risk of developing Alzheimer's disease |
摘要 |
Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
|
申请公布号 |
US5716828(A) |
申请公布日期 |
1998.02.10 |
申请号 |
US19950441001 |
申请日期 |
1995.05.15 |
申请人 |
DUKE UNIVERSITY |
发明人 |
ROSES, ALLEN D.;STRITTMATTER, WARREN J.;SALVESEN, GUY S.;ENGHILD, JAN;SCHMECHEL, DONALD E. |
分类号 |
G01N33/53;A61K39/395;C07K1/28;C07K14/755;C07K14/775;C07K16/00;C07K16/18;C12N15/09;C12P21/08;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|