SYNTHETIC OLIGOYPEPTIDES SPECIFICALLY INTERACTING WITH ANTIBODIES RAISED TO HEPATITIS C VIRUS, METHODS OF DIAGNOSIS HCV-INFECTION (VARIANTS)

摘要

FIELD: medicine, molecular biology, virology. SUBSTANCE: invention proposes to use synthetic oligopeptides which are fragments of nonstructural protein NS4 of hepatitis C virus and corresponding amino acid residues 1711-1732 and 1921-1940. For diagnosis of HCV-infection using peptides exhibiting immunoreactivity with respect to antibody to hepatitis virus C antigenic mixture consists combination of indicated synthetic oligopeptides. For diagnosis using combination of proteins and peptides exhibiting immunoreactivity with respect to antibody to hepatitis C virus or based on recombinant nuclecapside hepatitis C virus protein (HCcAg) antigenic mixture has additionally indicated synthetic oligopeptides. EFFECT: simplified method of diagnosis. 5 cl, 3 tbl