发明名称 |
Treatment of type 2 diabetes mellitus |
摘要 |
Antibody methods for blocking the effects of diabetes-associated peptide, or "amylin", a hormone found in the amyloid masses of Type 2 diabetics, are disclosed. This putative hormone has been discovered to function both to inhibit insulin secretion and to inhibit glycogen synthesis. Regulation is accomplished by blocking the binding of amylin or amylin agonists, including calcitonin gene related peptide (CGRP), or biologically active sub-peptides thereof. Inhibitors include antibodies directed to amylin and amylin agonist active sites. Other antagonists include anti-idiotype antibodies directed to antibodies directed to amylin.
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申请公布号 |
US5716619(A) |
申请公布日期 |
1998.02.10 |
申请号 |
US19940295361 |
申请日期 |
1994.08.23 |
申请人 |
AMYLIN PHARMACEUTICALS, INC. |
发明人 |
COOPER, GARTH J.S.;GREENE, JR., HOWARD |
分类号 |
A61K38/00;A61P3/10;C07K14/575;C07K16/26;(IPC1-7):A61K39/395 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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