| 摘要 |
PCT No. PCT/FR97/01377 Sec. 371 Date Jan. 25, 1999 Sec. 102(e) Date Jan. 25, 1999 PCT Filed Jul. 23, 1997 PCT Pub. No. WO98/03503 PCT Pub. Date Jan. 29, 1998Compounds selected from the group which consists of the compounds of formula (I), wherein each of X1 and X2 which are the same or different, is halogen or a C1-3 alkoxy group, R1 is H, CF3 or a C1-3 alkyl group, R2 is a hydrogen atom or an OH group, A is group (a), (b) or (c), B is a single bond, -CO-, -CO-CH2-, -CO-CH2-O-, -CO-CH=CH or -SO2-, m is 2 or 3, N is 0, 1, 2 or 3, R3 is a hydrogen atom or a methyl group and W is CH or N, the amidine group C(=NR2)NH2 being in the 2, 3 or 4 position on the aromatic ring, and addition salts thereof, are disclosed. A method for preparing said compounds, and the therapeutical use thereof, particularly for treating diseases in which bradykinin is involved, are also disclosed. |
