Phosphonic acid compounds, their production and use

摘要

PCT No. PCT/JP95/01328 Sec. 371 Date Aug. 11, 1995 Sec. 102(e) Date Aug. 11, 1995 PCT Filed Jul. 3, 1995 PCT Pub. No. WO96/01267 PCT Pub. Date Jan. 18, 1996The present invention relates to a compound of the general formula (I): <IMAGE> (I) wherein ring A is a benzene ring that may be substituted; Y is a divalent group as a constituent member of ring B forming a 5- to 8-membered ring; Q1 is a group of the formula -X-P(O)(OR1)(OR2) wherein X is a bond or a divalent group; R1 and R2, identical or different, are hydrogen or a lower alkyl, or may be combined together to form a ring; Q2 is hydrogen, a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; and the group of the formula -CON(Q1)(Q2) is connected to the a- or b-position carbon atom, or a salt thereof, which is useful as prophylactic and therapeutic agents of various metabolic bone diseases such as osteoporosis.