| 摘要 |
<p>Compounds of formula (I) inhibit the activity of endothelin. The symbols are defined as follows: R?1 and R2¿ are each directly bonded to a ring carbon and are each independently (a) hydrogen; (b) alkyl or alkoxy; (c) hydroxyl; (d) halo; or (e) amino; R?3 and R4¿ are each directly bonded to a ring carbon and are each independently (a) hydrogen; (b) alkyl alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z?1, Z2 and Z3¿; (c) halo; (d) hydroxyl; (e) cyano; (f) nitro; (g) -C(O)H or -C(O)R5; (h) -CO¿2?H or -CO2R?5¿; (i) -Z4-NR6R7; (j) -Z?4-N(R10)-Z5-NR8R9¿; or (k) R?3 and R4¿ together may also be alkylene or alkenylene, either of which may be substituted with Z?1, Z2 and Z3¿, completing a 4- to 8-membered saturated, unsaturated or aromatic ring together with the carbon atoms to which they are attached; and the remaining symbols are as defined in the specification.</p> |
