| 摘要 |
<p>Method and apparatus for non-invasively determining glucose level in fluid of subject, typically blood glucose level. A particular device (10) is mounted on the skin of the patient for a fixed period of time. The device (10) is mounted on the skin such that a substrate such as paper (12) or gel or an aqueous glucose solution carried by the device are in contact with the patient's skin. Water and/or glucose migrates between the substrate (12) or the aqueous glucose solution of the device. The degree of migration of the substance in question is monitored, for example the amount of glucose remaining in an aqueous solution of the device is measured at the end of the fixed period. This can be done by a conventional or other spectrophotometric method, for example. The glucose level is determined based on the degree of migration of the migrating substance. That is, the degree of migration is correlated with previously determined fluid glucose levels based on directly measured fluid glucose levels. In another approach, impedance of skin tissue is measured and the measurement is used with impedance measurements previously correlated with directly determined glucose levels to determine the glucose level from the newly measured impedance. It is thus possible to routinely non-invasively determine fluid glucose levels.</p> |
