RECOMBINANT MOSQUITO SALIVARY ALLERGENS

摘要

A recombinant mosquito salivary allergen for use in skin tests, immunoassays and allergy immunotherapy for allergic reactions to mosquito bites is provided. The recombinant allergen is produced by a cDNA encoding and IgE-binding protein or fragment thereof or analogue thereof which is found in mosquito saliva. The recombinant allergen may share common allergenicity among at least two species of mosquitos or may be species-specific. The present invention also provides a method of skin testing, an immunoassay and undertaking immunotherapy utilizing the recombinant salivary allergen and kits for practicing the methods of the invention. The present invention further provides antibodies directed against the recombinant salivary allergens.