| 摘要 |
<p>A method for preparing N-protected α-amino sulphinic acid salts having formula Y - NH - CR'R - SO2-, M+ is disclosed. An intermediate compound Y - NH - CR'R - R1 is reacted with a sulphinic hydroxyacid salt in a strongly basic medium. The resulting salts, wherein Y is an acyl grouping other than R' SO¿2?, where R' is methyl or PCH3C6H4, R is a halogenated carbon group, alkyl or aryl, R' is hydrogen, a halogenated carbon group, alkyl or aryl, and M?+¿ is a cation, are also disclosed. Furthermore, stable sulphonopeptides derived from said salts by electrophilic amination are disclosed.</p> |
