A PROCESS TO MANUFACTURE SUSTAINED RELEASE MEDICAMENTS

摘要

The subject invention is a process to manufacture a sustained release pharmaceutical tablet. The process includes granulation of inactive ingredients, such as hydroxypropyl cellulose, with active ingredients, such as nifedipine; followed by micronization of the granules. Additional granulation of further active or inactive ingredients is done with or without the micronized granules formed in the first step. All of the granules are then dried if necessary, lubricated, and compressed into tablets which slowly release the active ingredient over a controlled length of time.