| 摘要 |
<p>Novel compounds of formula (1) are useful to treat disorders responsive to openers of the large conductance calcium-activated potassium channels, wherein 'Het' is one of a select group of heterocyclic moieties; Z is independently for each occurrence selected from O or S; R?a, Rb and Rc¿ each are independently selected from hydrogen, halogen, OH, CF¿3?, NO2, or (a); provided R?c¿ is not hydrogen; and when R?a and Rb¿ are hydrogen, Rc may be a heterocyclic moiety selected from the group consisting of imidazol-1-yl, morpholinomethyl, N-methylimidazol-2-yl, and pyridin-2-yl; R?d and Re¿ each are independently selected form hydrogen, halogen, CF¿3?, NO2 or imidazol-1-yl; m, n and p each are independently selected from an integer of 0 or 1; and R?f and Rg¿ each are independently hydrogen; C¿1-4? alkyl; or R?f and Rg¿, taken together with the nitrogen atom to which they are attached, is a heterocyclic moiety selected from the group consisting of N-methylpiperazine, morpholine, thiomorpholine, N-benzylpiperazine and imidazolinone.</p> |
