发明名称 |
6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME |
摘要 |
6-Phenyltetrahydro-1,3-oxazin-2-one derivatives represented by general formula (I) and having a phosphodiesterase IV inhibitory effect, optically active substances thereof, pharmacologically acceptable salts thereof or their hydrates or solvates, and medicinal compositions containing the same, in particular preventives or remedies for inflammatory diseases and antiasthmatics, wherein R1 represents optionally substituted C1-8 alkyl, optionally substituted C3-7 cycloalkyl, etc.; R2 represents C1-4 alkyl; R3 represents H, optionally substituted C1-5 alkyl, etc.; R4 represents H or optionally substituted C1-6 alkyl; and R5 and R6 independently represent each H, optionally substituted C1-5 alkyl, etc.. These derivatives have potent effects of inhibiting phosphodiesterase (PDE) IV and bronchodilating and antiinflammatory effects.
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申请公布号 |
WO9804534(A1) |
申请公布日期 |
1998.02.05 |
申请号 |
WO1997JP02654 |
申请日期 |
1997.07.30 |
申请人 |
NIKKEN CHEMICALS CO., LTD.;INA, SHINJI;YAMANA, KENJIRO;NODA, KYOJI |
发明人 |
INA, SHINJI;YAMANA, KENJIRO;NODA, KYOJI |
分类号 |
A61P11/06;A61P17/04;C07D265/10;C07D413/04;C07D413/06;C07D413/12;C07D417/04;C07D417/12;(IPC1-7):C07D265/10;A61K31/535 |
主分类号 |
A61P11/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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