POTASSIUM CHANNEL INHIBITORS

摘要

Compounds of general formula (I) wherein R1 is H, alkyl or is selected from the group consisting of an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl and an optionally substituted carbocycloalkyl; R2 is selected from the group consisting of alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl and an optionally substituted carbocycloalkyl; R3 is hydrogen or methyl; R4 is hydrogen or methyl; X1 is C=O, C=S, or SO2; X2 is C=O or SO2; Y1 is O, (CH2)p, CH2O, HC=CH or NH; wherein p is 0, 1 or 2; Y2 is O, (CH2)q, HC=CH or NH; wherein q is 0 or 1; Z is H, OR5 or NR6R7; wherein R5 is H, (CH2)m-R8; or C(O)-(CH2)m-R8; m = 1 to 5; R8 is N(R9)2, N(R9)3L or CO2R9; wherein each R9 is independently selected from H or alkyl; and L is a counter ion; R6 is H or alkyl; R7 is H, alkyl or CO2R10; wherein R10 is alkyl; or pharmaceutically acceptable salts or prodrugs thereof are useful as potassium channel inhibitors and useful for the treatment of cardiac arrhythmias and cell proliferative disorders.