发明名称 |
SUBSTITUTED TRIAZOLO PYRIDAZINE DERIVATIVES AS INVERSE AGONISTS OF THE GABAA.ALPHA.5 RECEPTOR SUBTYPE |
摘要 |
The present invention provides a compound of formula (I), wherein L is O, S or NH; X is amino, phenyl or a five- or six-membered heterocycle, each of which is optionally substituted; Y is C1-4alkylidene; Z is an optionally substituted five- or six-membered heterocycle; and n is 1 or 2; or a pharmaceutically acceptable salt thereof or a prodrug thereof; processes for their preparation, their use in enhancing cognition and methods of treatment comprising their administration.
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申请公布号 |
CA2260900(A1) |
申请公布日期 |
1998.02.05 |
申请号 |
CA19972260900 |
申请日期 |
1997.07.17 |
申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
MCKERNAN, RUTH;MACLEOD, ANGUS MURRAY;REEVE, AUSTIN JOHN;CARLING, WILLIAM ROBERT;STERNFELD, FRANCINE;STREET, LESLIE JOSEPH |
分类号 |
A61K31/5025;A61P25/00;C07D487/04;C07D487/08;(IPC1-7):C07D487/04;A61K31/50;A61K31/505 |
主分类号 |
A61K31/5025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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