Chelating compounds, their chelates with paramagnetic metal ions, their preparation and use

摘要

Compounds which can chelate paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI), the compounds having formula (I) wherein R is a -(CH2)m-O-R2 group or hydrogen, R2 is a (C6-C10) aryl, or an alkyl(C1-C5)-aryl(C6-C10) group, substituted or not by a group L corresponding to a OH group or a OR3 group, wherein R3 is a linear or branched (C1-C5) alkyl group; or L is NH2, halogen, COOH or CONR4R5 wherein R4 and R5 are independently hydrogen, or a linear or branched (C1-C5) alkyl which can be substituted by 1-6 hydroxy groups and/or 1-6 alkoxy groups, R1 can have the same meanings as R, independently from it, except for hydrogen, Z is independently OH or OR6, or NR4R5 wherein R4 and R5 are as previously defined, and R6 is a (C1-C10) alkyl, linear or branched, which can be substituted by 1-6 hydroxyl and/or alkoxyl groups, m is between 1 and 5.