| 摘要 |
The alternans pattern of cycle-to-cycle variability in physiologic waveforms is assessed by applying transducers to a subject, recording physiologic signals, and analyzing the alternans pattern of variation in waveform morphology. Preferred embodiments include methods and apparatus for measuring and assessing alternans in the presence of physiologic stress, such as exercise, in order to induce or increase the amplitude of the alternans, improvements in signal processing to improve the sensitivity and specificity of the analysis, improvements to provide real-time analysis and feedback to the operator conducting the recording of physiologic signals, reduction in the effect of intercycle interval variability on waveform variability, reduction in the effects of respiration on the alternans measurement, improved means for determining the statistical significance of the alternans measurement, handling of abnormal beats such as atrial and ventricular premature beats, choosing of data epochs over which to perform the alternans measurement, using multiple electrodes to improve the accuracy of the alternans measurement, and combining measurement of alternans with other cardiovascular diagnostic tests to facilitate and improve the combined diagnostic capability.
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