Processes for the preparation of D-chiro-inositol

摘要

PCT No. PCT/JP94/01304 Sec. 371 Date Feb. 9, 1996 Sec. 102(e) Date Feb. 9, 1996 PCT Filed Aug. 8, 1994 PCT Pub. No. WO95/04711 PCT Pub. Date Feb. 16, 1995An aqueous solution of kasugamycin or its salt is either mixed with a strongly acidic ion-exchange resin of the H+-form in a reaction vessel, or is brought into contact with a strongly acidic ion-exchange resin of the H+-form in a column containing said resin, followed by heating said aqueous solution and the resin under an atmospheric pressure or an elevated pressure, thereby to effect hydrolytic reaction of kasugamycin. By this reaction, an acidic reaction solution containing D-chiro-inositol is produced. This acidic reaction solution containing D-chiro-inositol is separated from the strongly acidic ion-exchange resin. Subsequently, D-chiro-inositol is recovered from the reaction solution. For this recovery, the acidic reaction solution is passed successively through a column of a strongly acidic ion-exchange resin of the H+-form and through a column of a strongly basic ion exchange resin of the OH--form, so that a neutral aqueous eluate containing D-chiro-inositol is obtained. This neutral aqueous eluate is then concentrated and crystals of D-chiro-inositol are made to deposit, whereby D-chiro-inositol of a high purity can be harvested with high efficiency.