发明名称 |
Process improvement in the synthesis of N-[3-(3-cyano-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide |
摘要 |
The invention is a process improvement for producing N-[3-(3-cyano-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide which is useful as an anxiolytic, antiepileptic, sedative-hypnotic agent and skeletal muscle relaxant. The disclosed invention comprises reacting 3-dimethylamino-1-(3-N-ethyl-N-acetyl-aminophenyl)-2-propen-1-one or a suitable salt thereof with 3-aminopyrazole-4-carbonitrile or a suitable salt thereof in a mixture comprising water and acetic acid or a suitable salt thereof, rather than in acetic acid alone.
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申请公布号 |
US5714607(A) |
申请公布日期 |
1998.02.03 |
申请号 |
US19960758132 |
申请日期 |
1996.11.25 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
PADMANATHAN, THURAIRAJAH |
分类号 |
A61K31/505;A61P21/02;A61P25/04;A61P25/08;A61P25/20;C07D231/00;C07D239/00;C07D487/04;(IPC1-7):C07D487/04 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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