NOVEL DERIVATIVES OF INDANILYENE-ACETYLGUANIDINE, METHOD OF OBTAINING THEM, THEIR APPLICATION IN PRODUCTION OF PHARMACEUTIC GENTS AND PHARMACEUTIC AGENT AS SUCH

摘要

Indanylidineacetylguanidines I <CHEM> and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and X have the meanings given in the claims, are effective inhibitors of the cellular sodium/proton antiport (Na<+>/H<+> exchanger), which, in numerous diseases (essential hypertension, atherosclerosis, diabetes and the like) is also increased in those cells which are readily accessible for measurements, such as, for example, in erythrocytes, platelets or leukocytes.