发明名称 |
Novel tricyclic N-cyanoimines useful as inhibitors of farnesyl-protein transferase. |
摘要 |
Novel tricyclic N-cyanoimine compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic N-cyanoimines compound to a biological system. In particular, the method inhibits the abnormal growth of cells in mammals such as a human. |
申请公布号 |
ZA9706754(B) |
申请公布日期 |
1998.02.02 |
申请号 |
ZA19970006754 |
申请日期 |
1997.07.29 |
申请人 |
SCHERING CORPORATION |
发明人 |
ALAN B. COOPER;JAMES J. S. WANG;RAYMOND G. LOVEY;JAGDISH A. DESAI;ANIL K. SAKSENA;VIYYOOR M. GIRIJAVALLABHAN;RONALD J. DOLL |
分类号 |
A61K31/00;A61K31/4427;A61K31/443;A61K31/445;A61K31/4465;A61K31/4523;A61K31/4545;A61K31/47;A61K31/4709;A61K31/496;A61K31/505;A61K31/513;A61K31/535;A61K31/5375;A61K31/5377;A61P35/00;A61P43/00;C07D401/04;C07D401/12;C07D401/14;C07D405/14;C07D471/04;C07D521/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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