| 摘要 |
The present invention relates to the management of chronic pain without requiring administration of narcotics, and to self-management of pain on an outpatient basis. The invention further relates to facilitating detoxification and treatment of substance addiction. Accordingly, the present invention is broadly directed to a method for treating pain in a subject comprising administering via a nasal route a dose of ketamine effective to alleviate pain to a subject suffering from pain. The invention is further directed to a method for facilitating detoxification and treating substance addiction in a subject comprising administering via a nasal route a dose of ketamine effective to facilitate detoxification or treat substance addiction. In a further embodiment, the present invention provides for pulmonary administration of ketamine by inhalation. Nasal administration of ketamine advantageously allows for patient self administration of the drug, which provides for pain management or treatement of a substance addiction on an outpatient basis. Moreover, ketamine administration in nasal sprays and inhalers are generally socially acceptable. In a specific example, a patient suffering from intractable bladder pain controlled breakthrough pain by nasal administration of about 16 mg to about 32 mg of ketamine per dose.
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