SYNTHESIS OF 9-DESOXO-9a-AZA-11, 12-DEOXY-9a-METHYL-9a-HOMOERITHROMICYN A, 11,12-HYDROGENORTHOBORATE, A PROCESS FOR THE PREPARATION OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERITHROMYCIN DIHYDRATE (AZITHROMYCIN DIHYDRATE).

摘要

The preparation of azithromycin dihydrate from 9-deoxo-9a-AZA-11,12-deoxy-9a-methyl-9a-homoerithromycin A, 11,12-hydrogenorthoborate, which is obtained in a sequential process from 9-deoxo-6-deoxy-6,9-epoxy-9,9a-dihydro-9a-azahomoerithromycin A is a process which is performed mild conditions, and having good yields.