Novel coumarin quinolone carboxylic acids and processes for the preparation thereof

摘要

The present invention relates to novel coumarin quinolone carboxylic acids wherein the pyridone system is fused in 3,4-, 6,7- and 7,8-positions of the coumarin system, of the general formula I <CHEM> wherein R<1>R<2> = -NHCH=C(CO2R<6>)CO-, R<3> = NO2 or NH2, R<4> = R<5> = H, R<6> = H or C2H5; R<1>R<2> = -NHCH=C(CO2R<6>)CO-, R<3> = R<4> = H, R<5> = F, R<6> = H or C2H5; R<1>R<2> = -CO(CO2R<6>)C=CHNH-, R<3> = R<4> = R<5> = H, R<6> = H or C2H5; R<1>R<2> = R<3>R<4> = -NHCH=C(CO2R<6>)CO-, R<5> = H, R<6> = H or C2H5; R<1> = H or OH, R<2> = R<5> = H, R<3>R<4> = -NHCH=C(CO2R<6>)CO-, R<6> = H or C2H5; R<1> = OH, R<2> = R<3> = H, R<4>R<5> =-CO(CO2R<6>)C=CHNH-, R<6> = H or C2H5; R<1> = R<5> = H, R<2> = CH3 or CF3, R<3>R<4> = -CO(CO2R<6>)C=CHNH-, R<6> = H or C2H5, as well as pharmaceutically acceptable salts thereof. The object of the invention are also processes for the preparation of novel coumarin quinolone carboxylic acids and the biological action thereof.