RETROVIRAL PROTEASE INHIBITOR COMBINATIONS

摘要

The present invention is directed to a method for selecting a first and a second retroviral protease inhibitor for administration to a patient, the method comprising
(a) exposing said first retroviral protease inhibitor to a propagating culture of retroviruses and
(b) determining the retroviral inhibitory activity of one or more candidate retroviral protease inhibitors against a retroviral strain that emerges after step (a),
wherein said second retroviral protease inhibitor is selected from said candidate retroviral protease inhibitors based on its effectiveness against said retroviral strain.