HIV monoclonal antibody specific for the HTLV-IIImn gp120 envelope glycoprotein

摘要

A murine monoclonal antibody which specifically binds to a glycoprotein antigen having a molecular weight of about 12x104 daltons (gp120) present in the envelope of human T-lymphotropic virus IIIMN (HTLV-IIIMN) and capable of neutralizing the HTLV-IIIMN as determined by in vitro inhibition of syncytium formation but does not bind to other HTLV-III strains, or antigen-binding fragments, which is useful for prophylaxis, treatment and diagnosis of AIDS.