| 摘要 |
This invention relates to methods of treating neurological illnesses related to acetylcholine deficiency in the CNS including memory loss attending senility, Parkinson's disease, Down's syndrome or senile pugilistica by administering a therapeutically effective compound of the formula: <IMAGE> where R1, R2 and R3 are, independently, H, alkyl, halo, perhaloalkyl, hydroxy, alkoxy, aryl or arylalkyl; n is an integer from 0-5; R is azabicyclo[2.2.2]octyl or azabicyclo[2.2.1]heptyl when n1 is zero, or R is NR4R5 when n1 is 1, 2, 3, 4, or 5, in which R4 and R5 are alkyl or R4 and R5, taken with the nitrogen atom to which they are attached, are N-(substituted aryl)piperazinyl in which said substituent is alkoxy, halo or perhaloalkyl; N-(pyridyl)piperazinyl; N-(pyrimidinyl)piperazinyl; or 3-azabicyclo-[3.2.2]non-3-yl; X is oxygen or NH; n and n1 are, independently, one of the integers 0, 1, 2, 3, 4 or 5; or a pharmaceutically acceptable salt thereof.
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