发明名称 CARBAMIC ACID DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS, METHOD OF THEIR SYNTHESIS (VARIANTS) AND PHARMACEUTICAL COMPOSITION
摘要 FIELD: organic chemistry. SUBSTANCE: invention proposes derivatives of carbamic acid of the general formula (I): <EMI ID=0.192 HE=15 WI=21 TI=CHI> where R means group of the general formula (II) <EMI ID=0.193 HE=21 WI=18 TI=CHI> or (III) <EMI ID=0.194 HE=21 WI=18 TI=CHI> where R - phenyl(lower)alkyl; R - phenyl(lower)alkyl or hydrogen atom; R - hydrogen atom; R means group of the general formula (IV) <EMI ID=0.195 HE=27 WI=30 TI=CHI> or (V) <EMI ID=0.196 HE=36 WI=42 TI=CHI> where X - hydrogen atom and R<SP>7</SP>,R<SP>8</SP>,R<SP>9</SP>,R and R means lower alkyl, and pharmaceutically acceptable acid-additive salts, and a method of their synthesis. The synthesized compounds can be used in medicine, in part, in neurology (for Alzheimer disease treatment). EFFECT: improved method of synthesis. 10 cl, 1 tbl
申请公布号 RU2103271(C1) 申请公布日期 1998.01.27
申请号 SU19925052874 申请日期 1992.09.30
申请人 D 发明人 DEHNIZ MEHRI FLEHNAGAN;LOREHNS LEO MARTIN;DEHNIZ MEHRI FLEHNAGAN;LOREHNS LEO MARTIN
分类号 A61K31/40;A61K31/325;A61K31/41;A61K31/42;A61K31/445;A61K31/535;A61K31/55;A61P25/28;C07D207/26;C07D209/02;C07D223/14;C07D261/04;C07D307/94;C07D487/04;C07D491/048;C07D491/06;C07D491/10;C07D491/107;(IPC1-7):C07D487/04 主分类号 A61K31/40
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