| 摘要 |
A compound of the formula: (see fig, I) wherein L and M axe hydrogen atom, hydroxy, lower alkyl, hydroxy (lower) alkyl or oxo, provided that at least one of L and M is not hydrogen atom and that the five-membered ring may have one or two double bonds, X1 and X2 are hydrogen atom, halogen atom or lower alkyl, Y is -CH2-CH2-, -CH=CH-, -C=C- or -CO-CH2-, Z is -CH2-CH2-CH2-, -CH=CH-CH2 or -CH2-CH=CH-, R is hydxogen atom, lower alkyl, lower cycloalkyl, monocyclic aryl, monocyclic aryl (lower)alkyl or monocyclic aroyl(lower)alkyl, R2 is single bond or lower alkylene, R3 is lower alkyl which is unsubstituted or substituted with halogen, lower cycloalkyl which is unsubstituted or substituted with lower alkyl, monocyclic aryl which is unsubstituted or substituted with halogen or halo(lower)alkyl, or monocyclic aryloxy which is unsubstituted or substituted with halogen or halo(lower)alkyl, or a pharmaceutically acceptable salt when R1 is hydrogen atom.
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