N-{4-£BIS(2-CHLORETHYL)AMINO|PHENYLACETYL}-L-PHENYLALANIN, METHOD FOR PREPARING THEREOF, PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL FORMULATION

摘要

This invention belongs to the branch of pharmaceutical chemistry, it is namely used for producing remedy N-{4-[bis(2-chlorethyl)amino]phenyl acetyl} -L-alanine and the product phenalon, the formula of which is , the method for producing a compound which has this pharmaceutical composition and form of medicine. The production method described in this invention ensures the extrication and purification of active material of the remedy - phenalon. The invention also describes the pharmaceutical composition and form of medicine - tablets, which weigh 300 mg and correspond to the requirements of pharmacology. The main indications when treating patients with phenalon are hemoblastosis: malignant lymphomas (both Hodzhkin and non-Hodzhkin), lymphoepithelioma, chronic lymph-leucosis, melomical disease, Kaposi's sarcoma and some solid tumours - seminoma, ovarian cancer.