发明名称 |
OPTICAL RESOLUTION OF RACEMIC ALPHA-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-(HYDROXYDIPHENYLMETHYL)-1 -PIPERIDINEBUTANOL DERIVATIVES |
摘要 |
<p>A process and diastereomeric salts useful for the optical resolution of racemic alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol, 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylbenzeneacetic acid and lower alkyl 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylbenzeneacetates. The process comprises placing into solution a chiral resolving agent, either (+)/(-)-di-paratoluoyltartaric acid or (-)/(+)-mandelic acid, in an amount equimolar to a compound corresponding to the desired enantiomer of the above compound, precipitating the resulting diastereomeric salt between the chiral resolving agent and the target enantiomer and separating the enantiomer.</p> |
申请公布号 |
NZ284277(A) |
申请公布日期 |
1998.01.26 |
申请号 |
NZ19950284277 |
申请日期 |
1995.04.10 |
申请人 |
MERRELL PHARMACEUTICALS INC |
发明人 |
NAKAMURA, MITSUO;SHIGA, MASATOSHI |
分类号 |
C07B57/00;C07D211/22;(IPC1-7):C07D211/22 |
主分类号 |
C07B57/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|