cis-SUBSTITUTED AMINOCYCLOPROPANE DERIVATIVES

摘要

Antibacterial drugs exhibiting potent antibacterial effects against various bacteria and high safety, which comprise compounds of general formula (1), or salts of the compounds or hydrates thereof: wherein R<1> and R<2> are each hydrogen or alkyl; n is an integer of 1 to 3; R<3> is alkyl, alkenyl, halogenoalkyl, cyclic alkyl, aryl, heteroaryl, alkoxyl or alkylamino; R<4> is hydrogen or alkylthio; R<5> is hydrogen, amino, hydroxyl, mercapto, halogenomethyl, alkyl, alkenyl, alkynyl or alkoxyl; X<1> is halogeno or hydrogen; A is nitrogen or (II); X<2> is hydrogen, amino, halogeno, cyano, halogenomethyl, halogenomethoxyl, alkyl, alkenyl, alkynyl or alkoxyl; and Y is hydrogen, phenyl, acetoxymethyl, pivaloyloxymethyl, ethoxycarbonyl, cholyl, dimethylaminoethyl, 5-indanyl, phthalidyl, 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl, 3-acetoxy-2-oxobutyl, alkyl, alkoxymethyl or phenylalkyl.