CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR

摘要

Disclosed is a method of treating a subject with a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to the subject a therapeutically effective amount of a compound represented by structural formula (I) and physiologically acceptable salts thereof. Z is a substituted or unsubstituted aromatic group. Y is a covalent bond, -O- or -CO-. n is an integer from one to about five. X is a covalent bond or -CO-. Ra is an aliphatic or a substituted aliphatic group; Rb is an aliphatic group substituted with an aromatic group or substituted aromatic group; and, taken together with the nitrogen atom bonded to Ra and Rb, can form a substituted or unsubstituted non-aromatic heterocyclic ring.