| 摘要 |
PCT No. PCT/GB97/01748 Sec. 371 Date Apr. 8, 1999 Sec. 102(e) Date Apr. 8, 1999 PCT Filed Jun. 26, 1997 PCT Pub. No. WO98/00438 PCT Pub. Date Jan. 8, 1998Bisphosphonate derivatives of hydroxy steroids which are bone resorption inhibitors or bone formation stimulators, the derivatives having at least one group A in place of a hydroxy group on the steroid molelcule, where A is a group of forumla (A) where X is: (i) St-O-CO- where St is the residue of the hydroxy steroid given by removal of an OH group; or (ii) R1-O-CO- where R1 is an alkyl, alkenyl, cycloalkyl, aralkyl or aryl group, any of which may optionally be substituted, and the salts and solvates of these compounds. The steroid is typically 17 beta -oestradiol, oestrone, testosterone, norethindrone, androsterone, norethandrolone or nandrolone. The derivatives can be used in the treatment of bone disorders such as osteoporosis. |
