Thrombin inhibitors

摘要

Bifunctional peptide thrombin inhibitors and methods of their manufacture are provided. The inhibitors have an anion-binding exosite associating moiety joined to a catalytic site directed moiety. A spacer peptide and a non-peptide linker moiety enable both the anion-binding exosite associating moiety and the catalytic site directed moiety to bind simultaneously to a thrombin molecule thereby permitting the treatment of thrombosis.