发明名称 |
Method to produce granulocyte colony stimulating factor from immortalized avian t lymphocytes and method to produce immortalized cells |
摘要 |
Immortal avian T lymphocyte cell lines which produce and secrete immune lymphokines are disclosed. These cell lines may be produced from T cells recovered from fowl which have been hyperimmunized in vivo. The activated T cells are first exposed in vitro to a mitogen effective for secondary stimulation thereof, and then virally transformed to produce an immortal cell line. When cultured in vitro, the cell lines produce and secrete immune lymphokines which may be administered to fowl to increase their resistance to infections. |
申请公布号 |
AU3512697(A) |
申请公布日期 |
1998.01.21 |
申请号 |
AU19970035126 |
申请日期 |
1997.06.30 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF;TEXAS A & M UNIVERSITY SYSTEM, THE |
发明人 |
MICHAEL H. KOGUT;JOHN R DELOACH;LARRY H. STANKER;RITA B. MOYES;BILLY M. HARGIS |
分类号 |
A61K38/00;C07K14/52;C07K14/535;C12N5/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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