| 摘要 |
The present invention relates to compounds of the formula (I): <IMAGE> (I) wherein Ar1 represents optionally substituted phenyl; Ar2 represents aryl; benzhydryl; or benzyl; wherein each aryl and heteroaryl and each phenyl moiety of benzyl and benzhydryl may be substituted; R1 represents H or a group of the formula Z-R2; R2 represents H, CO2R7, CONR7R8, NR7R8, NR7COR9, NR7SO2R8, trifluoromethyl, heteroaryl or -O-heteroaryl, each of which heteroaryl groups are as previously defined and may be optionally substituted, or R2 represents a group selected from phenyl, piperazinyl, piperidinyl, spiro-fused piperidinyl, tetrahydroquinolinyl or tetrahydroisoquinolinyl, each of which may be substituted; R3, R4, R5 and R6 each independently represent H or C1-4alkyl; R7 and R8 each independently represent H, C1-6alkyl, trifluoromethyl, phenyl or benzyl; Q represents O or S; X represents a group selected from -CR3R4CR5R6-, -CR3=CR4-, -C(OH)R3CR4R5-, -CR3R4C(OH)R5-, -C(O)CR3R4- and -CR3R4C(O)-; Y represents a C1-4alkylene chain; and Z represents a straight or branched C1-6alkylene or C3-6alkenylene chain with the proviso that the alkenylene double bond does not terminate at a carbon atom attached to a nitrogen atom; and pharmaceutically acceptable salts thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, emesis and postherpetic neuralgia.
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