CHIMERIC MONOCLONAL ANTIBODY INTERACTING WITH HUMAN PLACENTAL ALKALINE PHOSPHATASE, VARIABLE REGION OF HEAVY gamma-CHAIN OF CHIMERIC MONOCLONAL ANTIBODY, VARIABLE REGION OF LIGHT K-CHAIN OF CHIMERIC MONOCLONAL ANTIBODY, FRAGMENT OF CDNA ENCODING VARIABLE REGION OF HEAVY gamma-CHAIN OF CHIMERIC MONOCLONAL ANTIBODY AND FRAGMENT OF CDNA ENCODING VARIABLE REGION OF LIGHT K-CHAIN OF CHIMERIC MONOCLONAL ANTIBODY

摘要

FIELD: medicinal biotechnology, biochemistry, molecular biology. SUBSTANCE: invention relates to methods of preparing the modified antibodies and their fragments interacting with placental alkaline phosphatase. At least one light and/or heavy antibody chain has variable region where sites determining complementarity of binding with murine antigen were inserted. Also, fragments of cDNA encoding variable regions of heavy and light chains of chimeric antibody were obtained. Invention can be used for preparing agents inhibiting cancer cell proliferation. EFFECT: improved method of preparing. 6 cl, 18 dwge