| 发明名称 |
STRAIN OF HUMAN TRANSPLANTED CELLS CEM-K SHOWING RESISTANCE TO HIV-INFECTION |
| 摘要 |
FIELD: medicinal biotechnology, virology. SUBSTANCE: strain is obtained by the successive passages of lymphoblastoid human cellular line CEM showing sensitivity to HIV-infection in thymusless mice of line BALB/c. Strain shows rise of polyploid (2n = 90), additionally changed chromosomes, enhanced expression of antigen CD 95 and absence of expression of antigen CD 4. Strain can be used as a safe model for investigation of interaction mechanisms of HIV with cell-target and for study of HIV-infection in vitro. EFFECT: cellular strain indicated above. 2 dwg, 3 tble |
| 申请公布号 |
RU2102477(C1) |
申请公布日期 |
1998.01.20 |
| 申请号 |
RU19950122192 |
申请日期 |
1995.12.28 |
| 申请人 |
NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT VIRUSOLOGII IM. |
发明人 |
KARAMOV EH.V.;PASHKOVA T.A.;REVAZOVA E.S.;BARYSHNIKOV A.JU.;RUDNEVA I.A.;KUSHCH A.A.;GUSHCHINA E.A.;KORNILAEVA G.V.;KARAMOV EH.V.;PASHKOVA T.A.;REVAZOVA E.S.;BARYSHNIKOV A.JU.;RUDNEVA I.A.;KUSHCH A.A.;GUSHCHINA E.A.;KORNILAEVA G.V. |
| 分类号 |
C12N5/00;C12N5/071;C12N5/10 |
主分类号 |
C12N5/00 |
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