发明名称 |
Method of extracting sennosides A, B and A1 |
摘要 |
Sennosides A, B and Al of the formula: <IMAGE> which are substantially free from sennosides C, D and Dl, and from aloe-emodin derivatives, are prepared by a process wherein a) a sennoside mixture is reduced to rhein-9-anthrone-8-glucoside and aloe-emodin-9-anthrone-8-glucoside, b) a liquid-liquid partitioning of the compounds obtained is carried out between a polar organic solvent which is only partly miscible with water and an aqueous phase and c) the rhein-9-anthrone-8-glycosides contained after the partitioning in the aqueous phase is again oxidized to the corresponding sennosides and these are recovered.
|
申请公布号 |
US5710260(A) |
申请公布日期 |
1998.01.20 |
申请号 |
US19950614772 |
申请日期 |
1995.12.21 |
申请人 |
MADAUS AG |
发明人 |
CARCASONA, ALFONS;GRIMMINGER, WOLF;HIETALA, PENTTI;ZAESKE, HELGA;WITTHOHN, KLAUS |
分类号 |
C07H15/24;(IPC1-7):C07H15/244;C07H1/00;A61K35/78 |
主分类号 |
C07H15/24 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|