| 摘要 |
Herein described are radiolabeled compounds useful to image D4 receptors in vivo, of formula (I), wherein X<1> is selected from NH, O and S; X<2> is selected from CH and N; Z is selected from iodide, cyano, nitro, tri(loweralkyl)tin and a radioisotopic iodide; and R<1> is selected from H, lower alkyl, piperonyl, C1-4alkenyl, C1-4alkynyl and C1-4alkenyl substituted with one of iodide, tri(loweralkyl)tin and radioisotopic iodide; with the provisos that: (1) when one of Z and R<1> is radioisotopic, the other of Z and R<1> is not or does not incorporate iodide; and (2) when one of Z and R<1> is or incorporates tri(loweralkyl)tin, the other of Z and R<1> is not or does not incorporate iodide or radioisotopically labeled iodide. The radiopharmaceutical compounds are useful particularly to image localisation of D4 receptor in the human brain, and can therefore aid in the diagnosis of schizophenia and other medical conditions in which the D4 receptor is implicated.
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