A gene delivery system is made of enzymatically degradable polymeric cation and nucleic acid (DNA or RNA) nanospheres optionally with a linking moiety or a targeting ligand attached to the surface. The delivery system can be made by a simple method of coacervation. Targeting ligands can be attached to the nanosphere directly or via a linking moiety. The linkage design allows the attachment of any molecule onto the nanosphere surface including antibodies, cell adhesion molecules, hormones and other cell-specific ligands.
申请公布号
WO9801162(A2)
申请公布日期
1998.01.15
申请号
WO1997US13116
申请日期
1997.07.09
申请人
THE JOHNS HOPKINS UNIVERSITY
发明人
ROY, KRISHNENDU;MAO, HAI-QUAN;TRUONG, THOMAS;AUGUST, THOMAS;LEONG, KAM, W.