| 摘要 |
<p>Disclosed are substantially pure nucleic acid sequences encoding vertebrate cdc37. The protein encoded by this nucleic acid is characterized by the ability to bind specifically to mammalian proteins selected from the group consisting of cdk4, cyclin D, cdk2, Rb, hsp90, hsp60, hsp70, Raf-1, MEK-1, SAPK, MAPK, ERK1, P13-K and the src family of tyrosine kinases. In addition, the protein is further characterized by the ability to bind glycosaminoglycan. Also disclosed are diagnostic and therapeutic applications based on the isolation of the nucleic acid sequences.</p> |
