发明名称 |
NOVEL PURINE DERIVATIVES |
摘要 |
Purine derivatives represented by general formula (I), their tautomers or pharmaceutically acceptable salts thereof, and interferon secretion inducers, antiviral agents and anticancer drugs containing the same. In said formula (I) R<2> represents hydrogen or hydrocarbyl (wherein -CH2- not directly bonded to the purine skeleton and CH2 in -CH3 not directly bonded to the purine skeleton may be replaced by carbonyl, sulfonyl, -O- or -S-; =CH2 may be replaced by =O or =S; and C-H in -CH2 not directly bonded to the purine skeleton, C-H in -CH3 not directly bonded to the purine skeleton, C-H in > CH not directly bonded to the purine skeleton, C-H in =CH- not directly bonded to the purine skeleton and C-H in =CH2 may be replaced by N, C-halogeno or C-CN); R<6> represents hydroxy or amino optionally substituted by one or two hydrocarbon groups; R<8> represents hydroxy, mercaptor, acyloxy or oxycarbonyl substituted by hydrocarbyl; and R<9> represents hydrocarbyl (wherein -CH2- not directly bonded to the purine skeleton and CH2 in -CH3 not directly bonded to the purine skeleton may be replaced by carbonyl, sulfonyl, -O- or -S-; =CH2 may be replaced by =O or =S; and C-H in -CH2 not directly bonded to the purine skeleton, C-H in -CH3 not directly bonded to the purine skeleton, C-H in > CH not directly bonded to the purine skeleton, C-H in =CH- not directly bonded to the purine skeleton, C-H in =CH2 and C-H in CH may be replaced by N, C-halogeno or C-CN).
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申请公布号 |
WO9801448(A1) |
申请公布日期 |
1998.01.15 |
申请号 |
WO1997JP02310 |
申请日期 |
1997.07.03 |
申请人 |
JAPAN ENERGY CORPORATION;HIROTA, KOHSAKU;ISOBE, YOSHIAKI;CHIBA, NOBUYOSHI;SATOH, HARUMI;TAKAKU, HARUO;MATSUI, HIROYUKI;OGITA, HARUHISA |
发明人 |
HIROTA, KOHSAKU;ISOBE, YOSHIAKI;CHIBA, NOBUYOSHI;SATOH, HARUMI;TAKAKU, HARUO;MATSUI, HIROYUKI;OGITA, HARUHISA |
分类号 |
C07D473/00;C07D473/30;C07D473/34;(IPC1-7):C07D473/34;A61K31/52 |
主分类号 |
C07D473/00 |
代理机构 |
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代理人 |
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