New heterocyclic biaryl compounds and their use in human or veterinary medicine and in cosmetics

摘要

Biaryl heterocyclic compounds of formula (I) and their salts are new. Z1 = O, S or NR'; R1+R2 = 5- or 6-membered ring (optionally substituted by one or more Me and/or optionally interrupted by SO, SO2, O or S); R3 = H, lower alkyl, lower alkenyl, lower alkynyl, halo, CN, OR7, C(O)R8 or NRR'; R4 = H, lower alkyl, halo, OR7 or lower acyl; Ar = 4-(R5)-phenyl (substituted by R6), 2-(R5)-pyridin-5-yl, 3-(R5)-pyridin-6-yl or furanyl, thiophenyl, 1-(R9)-pyrrolyl, thiazolyl or 1-(R9)-imidazolyl (all substituted by R5); R5 = Me, (CH2)pOR7, (CH2)pC(O)R8, -C IDENTICAL C-C(O)R8 or C(R10)=C(R11)(C(O)R8); R6 = H, halo, lower alkyl, lower acyl, or OR7; R7 = H, lower alkyl, aryl, aralkyl, polyhydroxyalkyl, polyether, or lower acyl; R8 = H, lower alkyl, NRR' or OR12; R9 = H, lower alkyl or lower acyl; R10,R11 = H or lower alkyl; R12 = H, lower alkyl, mono- or poly-hydroxyalkyl, optionally substituted aryl or aralkyl or residue of a sugar or an aminoacid; R,R' = amine-protecting group, H, lower alkyl, or a residue of an aminoacid or a sugar; or NRR' = heterocycle; m = 0 or 1; and p = 0-3. 15 Compounds (I) are specifically claimed e.g.: 4-(3,5,6,7,8-pentamethyl-2,3,5,6,7,8-hexahydronaphthoÄ2,3-bÜfuran-3-yl )-benzoic acid.