发明名称 |
ADENOVIRUS E4 PROTEINS FOR INDUCING CELL DEATH |
摘要 |
The present invention relates to a pharmaceutical agent for induction of apoptosis for the treatment of human diseases which involve inappropriate cell survival, which includes adenovirus E4orf4, an analog or a biologically active fragment thereof and/or adenovirus E4orf6, an analog or a biologically active fragment thereof. There is also provided a pharmaceutical composition for the treatment of human diseases which involve inappropriate cell survival, which comprises a therapeutic amount of adenovirus E4orf4, an analog or a biologically active fragment thereof and/or adenovirus E4orf6, an analog or a biologically active fragment thereof in association with a pharmaceutical carrier. Included in the invention are methods for identifying compounds as analogs of the adenovirus E4 death proteins.
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申请公布号 |
CA2259152(A1) |
申请公布日期 |
1998.01.15 |
申请号 |
CA19972259152 |
申请日期 |
1997.07.03 |
申请人 |
BRANTON, PHILIP E.;TEODORO, JOSE G.;MARCELLUS, RICHARD C.;LAVOIE, JOSEE N.;SHORE, GORDON C. |
发明人 |
BRANTON, PHILIP E.;TEODORO, JOSE G.;MARCELLUS, RICHARD C.;LAVOIE, JOSEE N.;SHORE, GORDON C. |
分类号 |
C12N15/09;A61K38/00;A61K45/00;A61K48/00;A61P35/00;A61P43/00;C07K14/075;C12N15/34;C12Q1/02;(IPC1-7):A61K48/00;A61K38/16;C12Q1/42;A61K31/70;C12Q1/70 |
主分类号 |
C12N15/09 |
代理机构 |
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主权项 |
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地址 |
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