A NOVEL HUMAN UBIQUITIN-CONJUGATING ENZYME TECHNICAL FIELD

摘要

The present invention provides a polynucleotide (ubcp) which identifies and enco des a novel ubiquitin-conjugating enzyme (UBCP). The invention provides for genetically engineered expression vectors and host ce lls comprising the nucleic acid sequence encoding UBCP. The invention also provides for the use of substantially purified UBCP and its a gonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the tr eatment of diseases associated with the expression of UBCP. Additionally, the invention provides for the use of antisense molecules to ubcp in pharmaceutical compositions for treatment of diseases associated with the expression of UBCP. The invention also describes di agnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybrid ize with the genomic sequence or the transcript of ubcp or anti-UBCP antibodies which specifically bind to UBCP.